Desiree Lewis has taught literary studies at Wits, UCT, UKZN, and UWC. She has been a Fulbright scholar-in-residence, a research associate at the Nordic Africa Institute in Uppsala Sweden, and a visiting researcher and lecturer in the United States and Sweden. She currently serves on the editorial boards of four academic journals and is a Council Member of the National English Literary Museum. Lewis has also been active in developing feminist intellectual activist networks throughout Africa; within South Africa, and in the Western Cape.
Lewis produces accessible writings on feminism and gender, and mentors new writers. Her book, Living on a Horizon: Bessie Head and the Politics of Imagining, was published in 2007.